News Archive
24 May 2011
Tal Golesworthy, the inventor of the ExoVasc® and the first recipient of it, celebrates the seventh anniversary of the operation to implant it today. He will be celebrating the anniversary with members of the project team at the Royal Brompton Hospital in London.

May 2011
The June 2011 edition of Heart features an editorial by Tom Treasure and John R Pepper entitled "Aortic root surgery in Marfan
syndrome". You can download a copy of the article here.
March 2011
On 19 March 2011 Tal Golesworthy and Professor John Pepper were keynote speakers at the Technology in Medicine and Surgery Conference at Imperial College in London. Their paper was called Exovasc™: A pilgrimage of innovation.
The Technology in Medicine & Surgery Conference (TiMS) is a national and pan-disciplinary event. Its ethos is to inspire the next generation of medical innovators and to expose them to the frontiers of medical technology and invention.
TiMS aims to foster a culture of always seeking to improve on the status quo by interdisciplinary collaborations, where students and professionals from various disciplines bring their skills and expertise to the table to solve a common problem. To find out more, visit the TiMS website.
January 2011
In the 17 January 2011 edition of The Engineer is an article on the development of the ExoVasc®. The article is called "UK engineer develops own life-saving implant" and you can read the article here.
September 2010
Just published in the Journal of the Royal Society of Medicine features an article by John Pepper, KM John Chan, Jemyrr Gavino, Tal Golesworthy, Raad Mohiaddin and Tom Treasure on the EARS project. It is called "External aortic root support for Marfan syndrome: early clinical results in the first 20 recipients with a bespoke implant" and you can download a copy of the article here.
14 June 2010
The EARS project is featured in the latest edition of The TCT Magazine, which covers software and technology for product development and manufacturing. The article is called "To the heart of the matter –
CRDM employs rapid manufacturing for a cardio vascular implant" and you can read the article here.
20 May 2010
Just published in the British Medical Journal is an article written by Camilla Allen in which she describes her 'Patient’s Journey'. In this article Camilla describes how having an external aortic root support allowed her to go through a safe pregnancy and give birth to her daughter.
You can download the article here.
22 March 2010
Saturday 13 March saw the annual Marfan Association Information Day at St George's Hospital in London where the EARS project was presented at exhibition by Tal Golesworthy and Exstent CEO Peter Gibson. A presentation on the current progress of the project was displayed and Tal Golesworthy took part in the expert panel Q&A session.

An impromptu "birthday" party was held in which Tal, whose ExoVasc® support will be "6" this year, was joined by 3 other ExoVasc® recipients who will reach 5, 2 and 2 years respectively in 2010.
1 February 2010
Professor Tom Treasure, a clinical advisor to Exstent Ltd, has published an article, "The evolution of aortic root surgery for Marfan syndrome" in
Interactive CardioVascular and Thoracic Surgery. You can download the article here.
26 January 2010
The ExoVasc® external aortic root support has been the subject of several newspaper articles and a television news report since the start of 2010. Follow the links below to read the articles and watch the report.

8 December 2009
The company has reached two significant milestones in its clinical experience with the ExoVasc® external aortic root support. In late October the 20th patient received their ExoVasc® support. This month also sees the collective total of post-operative patient experience reach 50 years.
A paper describing the follow up on the first 10 patients has been accepted for publication in the Journal of Interactive CardioVascular and Thoracic Surgery.
30 June 2009
Following the completion of the initial clinical trial the Clinical Practice Committee at the Royal Brompton Hospital has approved the device for use in the treatment of suitable patients with a dilated aorta due to Marfan syndrome.
1 June 2009
The project to introduce the ExoVasc® external aortic root support reached an important milestone last month when the first patient to receive the ExoVasc® support – inventor Tal Golesworthy – celebrated the fifth anniversary of receiving the implant that pioneered the procedure.
The occasion was marked by a gathering in London on 22 May that was attended by ten of the nineteen patients who have now received the ExoVasc® implant, together with members of their families, surgeons and members of the company.
Proposing a vote of thanks at the celebration, Professor Tom Treasure spoke of the advances in cardiovascular surgery that made this type of procedure possible and commended Tal Golesworthy for his ingenuity. Professor John Pepper paid tribute to all of the patients who had entered the trial to pioneer the procedure. In his address, Tal Golesworthy thanked the many members of the team of people that had made this advance possible.
10 June 2009
There is a paper on the EARS project in this month's edition of the European Journal of Cardio-Thoracic Surgery. Called "Unknown unknowns: the aorta through the looking glass", it was written by
Tom Treasure, Tal Golesworthy, Warren Thornton, Michael Lamperth, Raad Mohiaddin, Robert H. Anderson, Steve Gallivan and John Pepper. Visit the European Journal of Cardio-Thoracic Surgery's website to read the article in full.
6 April 2009
Tal Golesworthy and Peter Gibson attended the Marfan Information Day at St George’s Hospital London earlier this month with an exhibition to illustrate the ExoVasc® external aortic support. At this valuable event organised by the Marfan Association UK, we had the opportunity to speak to many families with members facing aortic root surgery, who were keen to learn more about the benefits of the new approach that is the subject of the current clinical trial at the Royal Brompton Hospital.
23 January 2009
A further two patients have been included in the clinical trial of the Exovasc® external aortic support in the last seven weeks and a further patient is scheduled for surgery in the coming week. Progress in the trial is dependent on the number of suitable patients with Marfan syndrome who are referred to Professor John Pepper at the Royal Brompton Hospital and are suitable to receive their ExoVasc® external aortic supports, and we are encouraged to add several further patients within a short time. The experience with all of the recent cases is that surgery is relatively short and patients do not require cardiopulmonary bypass.
17 November 2008
The first patient to receive the ExoVasc® external aortic support – inventor Tal Golesworthy – has now reached the four and a half year anniversary of receiving the implant that pioneered the procedure.
A recent MRI scan confirmed the findings in all of the patients in the trial to date: the implant appears to halt any further increase in the diameter of the ascending aorta.
"I am delighted to read the stories posted by more recent patients who have received the implant." says Tal. He adds, "It is good to see others sharing the relief from worrying about the future and not having the drawbacks associated with anticoagulant therapy. I look forward to my fifth birthday and many more thereafter!"
13 October 2008
A further patient received the ExoVasc® support in late September. For Professor John Pepper this successful operation on an 18-year old patient adds new data to the clinical trial. Results on the 12 – 48 month follow-up of the first group of patients in the trial are currently being analysed in preparation for the publication of a scientific paper.
20 August 2008
Exstent Limited has been shortlisted by the judging panel to present its work on the 'Development of and individually tailored external root support for Marfan Syndrome' for the final of the Medical Futures Innovation Awards for 2008.
Professor John Pepper and Exstent Technical Director Mr Tal Golesworthy will present to the judging panel at the British Cardiovascular Society in September. For further information see www.medicalfutures.co.uk.
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