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Clinical Advisors

Exstent Limited is fortunate to have a highly skilled and well-respected team of clinical advisors. They are all recognised experts in their field.

Professor John Pepper

John PepperJohn Pepper is a consultant surgeon at the Royal Brompton & Harefield NHS Trust. He joined the ExoVasc® project in January 2001.

Reference List

  1. Diseases of the aorta: overview. Curr Opin Cardiol 1986;1:641-2.
  2. Biglino G, Whitehorne M, Pepper JR, Khir AW. Pressure and flow-volume distribution associated with intra-aortic balloon inflation: An in vitro study. Arif Organs 32(1) Jan 2008
  3. John AS, Mongillo M, Depre C, Khan MT, Rimoldi OE, Pepper JR, Dreyfus GD, Pennell, DJ, Camici PG. Pre- and post-synaptic sympathetic function in human hibernating myocardium. Eur J Nucl Med Mol Imaging 2007
  4. Purcell H, Pepper J. An arm and a leg to protect the heart? The Lancet 2007; ­370: 542-543
  5. Wei Li, Susanna Price, Christine A O'Sullivan, Pankaj Kumar, Xu Y. Jin, Michael Y. Henein, John R. Pepper. Medium-term outcome of Toronto aortic valve replacement:  Single center experience. Int. J. Caridiol. 2007
  6. Ali A, Pepper J. Reoperative surgery on the aortic valve. J Cardiovasc Surg 2007; ­48: 791-5
  7. Biglino G, Kolyva C, Whitehorne M, Pepper JR, Khir AW. The effect of shape and angle on intra-aortic balloon pump performance. Int J Artif Organs 30(8) Aug 2007
  8. Goodman H, Parsons A, Davison J, Preedy M, Peters E, Shuldham C, Pepper J, Cowie MR. A randomised controlled trial to evaluate a nurse-led programme of support and lifestyle management for patients awaiting cardiac surgery 'Fit for surgery: Fit for life' study. Eur J Cardiovasc Nurs 19 Dec 2007
  9. Haj-Yahia S, Mittal T, Birks E, Carby M, Petrou M, Pepper J, Dreyfus G, Amrani M.
    Lung fibrosis as a potential complication of the hemostatic tissue sealant, biologic glue (Bioglue). J Thorac Cardiovasc Surg. 2007;133(5):1387-8
  10. John AS, Mongillo M, Depre C, Khan MT, Rimoldi OE, Pepper JR, Dreyfus GD, Pennell, DJ,
    Camici PG. Pre- and post-synaptic sympathetic function in human hibernating myocardium. Eur J Nucl Med Mol Imaging 2007
  11. Purcell H, Pepper J. An arm and a leg to protect the heart? The Lancet 2007; ­370: 542-543

Professor Tom Treasure

Tom TreasureTom Treasure is a heart and lung surgeon who been a research collaborator on the project since its inception.  He has an extensive portfolio of published research, reviews and teaching, related to the aorta over 25 years in consultant practice. (1-14)  He has a particular interest in the Marfan syndrome in which the aorta is prone to dissection.(12;15-24).

Reference List

  1. Diseases of the aorta: overview. Curr Opin Cardiol 1986;1:641-2.
  2. Treasure T. Diseases of the aorta: overview. Curr Opin Cardiol 1987;2:787.
  3. Treasure T. Diseases of the aorta: overview. Curr Opin Cardiol 1988;3:717.
  4. Tan PS, Aveling W, Pugsley WB, Newman SP, Treasure T. Experience with circulatory arrest and hypothermia to facilitate thoracic aortic surgery. Ann R Coll Surg Engl 1989 Mar;71(2):81-6.
  5. Treasure T, Raphael MJ. Investigation of suspected dissection of the thoracic aorta. Lancet 1991 Aug 24;338(8765):490-5.
  6. Treasure T. Imaging the dissected aorta. Br Heart J 1993 Dec;70(6):497-8.
  7. Treasure T, Simpson I. Aortic Dissection. In: Jackson G, editor. Difficult Concepts in Cardiology. London: Martin Dunitz; 1994, p. 183-200.
  8. Unsworth-White MJ, Buckenham T, Treasure T. Traumatic rupture of the thoracic aorta: computed tomography may be a dangerous waste of time. Ann R Coll Surg Engl 1994 Nov;76(6):381-3.
  9. Treasure T, Brecker S. The role of echocardiography in the diagnosis of aortic dissection. J Heart Valve Dis 1996 Nov;5(6):623-9.
  10. Davies MJ, Treasure T, Richardson PD. The pathogenesis of spontaneous arterial dissection. Heart 1996 May;75(5):434-5.
  11. Senthil V, Treasure T. Type B dissection involving a right-sided aortic arch. Eur J Cardiothorac Surg 1996;10(6):477-9.
  12. Brice G, Treasure T, Pumphrey C, Leech G, Child A. Serial echocardiography is of limited value in predicting aortic dissection in pregnant Marfan patients. European Journal of Paediatrics 1996;155:730.
  13. Treasure T. Imaging the thoracic aorta in the injured patient. Heart 1997 Sep;78(3):207-8.
  14. Beese RC, Allan R, Treasure T. Contrast-enhanced helical computerised tomography in the investigation of thoracic aortic injury. Ann R Coll Surg Engl 2001 Jan;83(1):10-3.
  15. Murgatroyd F, Child A, Poloniecki J, Treasure T, Pumphrey C. Does routine echocardiographic measurement of the aortic root diameter predict the risk of aortic dissection in the Marfan syndrome. European Heart Journal 1991;12 (abstract supplement):410.
  16. Simpson IA, de Belder MA, Treasure T, Camm AJ, Pumphrey CW. Cardiovascular manifestations of Marfan's syndrome: improved evaluation by transoesophageal echocardiography. Br Heart J 1993 Feb;69(2):104-8.
  17. Treasure T. Elective replacement of the aortic root in Marfan's syndrome. Br Heart J 1993 Feb;69(2):101-3.
  18. Murgatroyd F, Child A, Poloniecki J, DeBelder M, Treasure T, Pumphrey C. Echocardiographic and clinical features are inadequate guides to the management of patients with the Marfan syndrome. British Heart Journal 1993;68:84-5.
  19. Treasure T, Chow T, Gallivan S. Replacement of the aortic root in Marfan's syndrome. N Engl J Med 1999 Nov 4;341(19):1473-4.
  20. Treasure T, Reynolds C, Valencia O, Child A, Gallivan S. The timing of aortic root replacement in the Marfan syndrome: computer aided decision support. In: Enker J, editor. Cardiac Surgery and Concomitant Disease. Darmstadt: Springer; 1999, p. 91-8.
  21. Treasure T. Cardiovascular surgery for Marfan syndrome. Heart 2000 Dec;84(6):674-8.
  22. Golesworthy T, Lamperth M, Mohiaddin R, Pepper J, Thornton W, Treasure T. The Tailor of Gloucester: a jacket for the Marfan's aorta. Lancet 2004 Oct 30;364(9445):1582.
  23. Treasure T, Golesworthy TJ, Pepper J. A viable treatment option for Marfan's aorta or not? Lancet 2005 Feb 12;365(9459):568.
  24. Golesworthy T, Treasure T, Lamperth M, Pepper J. Reducing fear and the risk of death in Marfan syndrome: a Chaucerian pilgrimage. British Journal of Cardiology 2006;13:267-72.